Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial

نویسندگان

  • Johann Sebastian de Bono
  • Stephane Oudard
  • Mustafa Ozguroglu
  • Jean-Pascal Machiels
  • Ivo Kocak
  • Gwenaëlle Gravis
  • Istvan Bodrogi
  • Mary J Mackenzie
  • Liji Shen
  • Martin Roessner
  • Sunil Gupta
چکیده

Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton, UK (J S de Bono FRCP); Tulane University, New Orleans, LA, USA (A O Sartor MD); Hôpital Européen Georges Pompidou, Paris, France (S Oudard MD); Istanbul University, Istanbul, Turkey (M Ozguroglu MD); Odense University Hospital, Odense, Denmark (S Hansen MD); Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium (J-P Machiels MD); Masarykuv Onkologicky Ustav, Brno, Czech Republic (I Kocak MD); Institut Paoli Calmette Hôpital de Jour, Marseille, France (G Gravis MD); Orszagos Onkologiai Intezet, Kemoterapia C, Budapest, Hungary (I Bodrogi MD); London Health Sciences Centre, London, ON, Canada (M J Mackenzie MD); and Sanofi -Aventis, Malvern, PA, USA (L Shen PhD, S Gupta MD, M Roessner MS)

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Words of wisdom. Re: Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.

BACKGROUND Cabazitaxel is a novel tubulin-binding taxane drug with antitumour activity in docetaxel-resistant cancers. We aimed to compare the efficacy and safety of cabazitaxel plus prednisone with those of mitoxantrone plus prednisone in men with metastatic castration-resistant prostate cancer with progressive disease after docetaxel-based treatment. METHODS We undertook an open-label rando...

متن کامل

Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel tre

Cabazitaxel is a novel tubulin-binding taxane drug with antitumour activity in docetaxel-resistant cancers. We aimed to compare the efficacy and safety of cabazitaxel plus prednisone with those of mitoxantrone plus prednisone in men with metastatic castration-resistant prostate cancer with progressive disease after docetaxel-based treatment. We undertook an open-label randomised phase 3 trial i...

متن کامل

Progression of metastatic castrate-resistant prostate cancer: impact of therapeutic intervention in the post-docetaxel space

Despite the proven success of hormonal therapy for prostate cancer using chemical or surgical castration, most patients eventually will progress to a phase of the disease that is metastatic and shows resistance to further hormonal manipulation. This has been termed metastatic castrate-resistant prostate cancer (mCRPC). Despite this designation, however, there is evidence that androgen receptor ...

متن کامل

Reply from Authors re: Robert J. Hamilton. Metformin for Castrate-resistant Prostate Cancer: Learning More About an Old Dog's New Tricks. Eur Urol 2014;66:475–7: The Stage Is Set for Metformin

Pharma Web site. http://www.astellas.com/en/corporate/news/ detail/post.html. [5] De Bono JS, Logothetis CJ, Molina A, et al. Abiraterone and increased survival in metastatic prostate cancer. N Engl J Med 2011;364: 1995–2005. [6] Xtandi prescribing information. Astellas Web site. http://www. astellas.us/docs/us/12A005-ENZ-WPI.pdf. [7] De Bono JS, Oudard S, Ozguroglu M, et al. Prednisone plus ca...

متن کامل

Cabazitaxel: a novel second-line treatment for metastatic castration-resistant prostate cancer

Until recently, patients with castration-resistant prostate cancer (CRPC) had limited therapeutic options once they became refractory to docetaxel chemotherapy, and no treatments improved survival. This changed in June 2010 when the Food and Drug Administration (FDA) approved cabazitaxel as a new option for patients with CRPC whose disease progresses during or after docetaxel treatment. For mos...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2010